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PLOS BiologyCurrent methods for profiling <a href="https://fediscience.org/tags/HistoneModifications" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#HistoneModifications</a> require cell isolation & don't work with all tissue types. <a href="https://bird.makeup/users/jellevda" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@jellevda</a> &co adapt Targeted DamID (TaDa) to profile cell-type-specific <a href="https://fediscience.org/tags/histone" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#histone</a> marks throughout the genome, in vivo, without cell isolation <a href="https://fediscience.org/tags/plosbiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#plosbiology</a> <a href="https://plos.io/3Dw8sUD" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/3Dw8sUD</a>

PLOS BiologyWhy are animals like <a href="https://fediscience.org/tags/NakedMoleRat" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#NakedMoleRat</a> (NMR) so resistant to <a href="https://fediscience.org/tags/hypoxia" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#hypoxia</a> & <a href="https://fediscience.org/tags/cancer" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#cancer</a>? This study shows that embryonic fibroblasts from NMRs overexpress <a href="https://fediscience.org/tags/histone" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#histone</a> 1.2, reducing <a href="https://fediscience.org/tags/tumor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#tumor</a> formation via the NRF2/P62 pathway & improving resistance to hypoxia <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/4fYjAbd" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://plos.io/4fYjAbd</a>

Egon Willighagenbtw, replies with your favorite <a href="https://social.edu.nl/tags/histone" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#histone</a> question are most welcome too :) I have so many more, and looking for some distraction from writing project reports

Egon Willighagendear <a href="https://social.edu.nl/tags/biology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#biology</a> friends... I want to learn more about this:"<a href="https://social.edu.nl/tags/Histone" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Histone</a> H4 is encoded in multiple genes at different loci including: HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4G, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4."Who can recommend a good read? I have questions like: are all genes expressed at the same time? Equally? How are all regulated? Do they all code the exact same 102 AAs? what about the biology of the up to 33 other AAs?

Moritz NegwerHistone Serotonylation is one of the crazier epigenetic modifications - <a href="https://mstdn.science/tags/Serotonin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Serotonin</a>, the neurotransmitter, is shuttled into the nucleus and coupled to specific glutamine residues on the histone tails. This happens not only in the brain, but apparently also in the placenta, this new paper shows: Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome Chan et al., J Mol B 2024 <a href="https://doi.org/10.1016/j.jmb.2024.168454" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://doi.org/10.1016/j.jmb.2024.168454</a><a href="https://mstdn.science/tags/epigenetics" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#epigenetics</a> <a href="https://mstdn.science/tags/histone" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#histone</a>

The EMBO JournalHow do plants memorize heat exposure to be primed for future <a href="https://sciencemastodon.com/tags/heatstress" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#heatstress</a>?Isabel Bäurle et al show that selective <a href="https://sciencemastodon.com/tags/histone" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#histone</a> retention helps to preserve <a href="https://sciencemastodon.com/tags/chromatin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#chromatin</a> marks specifically at heat-induced genes in <a href="https://sciencemastodon.com/tags/Arabidopsis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Arabidopsis</a><a href="https://www.embopress.org/doi/full/10.15252/embj.2023113595" rel="nofollow noopener noreferrer" translate="no" target="_blank">https://www.embopress.org/doi/full/10.15252/embj.2023113595</a>

PLOS BiologyA role for <a href="https://fediscience.org/tags/HistoneMethylation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#HistoneMethylation</a> in metabolic regulation? <a href="https://fediscience.org/tags/Histone" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Histone</a> methyltransferases are co-regulated by <a href="https://fediscience.org/tags/TumorSuppressor" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#TumorSuppressor</a> Rb; altered expression controlled by Rb leads to reorganization of S-adenosyl methionine metabolism <a href="https://qoto.org/@PSarkies" class="u-url mention" rel="nofollow noopener noreferrer" target="_blank">@PSarkies</a> <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/3MhUfM4" rel="nofollow noopener noreferrer" target="_blank">https://plos.io/3MhUfM4</a>

The EMBO JournalGlobal histone H2B degradation regulates <a href="https://sciencemastodon.com/tags/insulin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#insulin</a>/#IGF signaling-mediated nutrient stressThe <a href="https://sciencemastodon.com/tags/ubiquitin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ubiquitin</a>-<a href="https://sciencemastodon.com/tags/proteasome" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#proteasome</a> system regulates <a href="https://sciencemastodon.com/tags/histone" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#histone</a> <a href="https://sciencemastodon.com/tags/H2B" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#H2B</a> exchange in mammalian cells and in C. elegans during development and starvation.<a href="https://www.embopress.org/doi/full/10.15252/embj.2022113328" rel="nofollow noopener noreferrer" target="_blank">https://www.embopress.org/doi/full/10.15252/embj.2022113328</a>

The EMBO JournalHow can <a href="https://sciencemastodon.com/tags/replication" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#replication</a> initiator ORC load replicative <a href="https://sciencemastodon.com/tags/helicases" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#helicases</a> in condensed chromatin? Structural and biochemical work by Franziska Bleichert and colleagues shows how ORCA recruits ORC to certain <a href="https://sciencemastodon.com/tags/histone" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#histone</a> marks, and also reorganizes local <a href="https://sciencemastodon.com/tags/chromatin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#chromatin</a> structure <a href="https://www.embopress.org/doi/full/10.15252/embj.2023114654" rel="nofollow noopener noreferrer" target="_blank">https://www.embopress.org/doi/full/10.15252/embj.2023114654</a>

The EMBO JournalInsights into the action of plant <a href="https://sciencemastodon.com/tags/WRKY" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#WRKY</a> <a href="https://sciencemastodon.com/tags/transcription" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#transcription</a> factors: Interaction with <a href="https://sciencemastodon.com/tags/histone" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#histone</a>-binding <a href="https://sciencemastodon.com/tags/OBERON" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#OBERON</a> proteins forms repressive complexes keeping drought stress response genes in check <a href="https://www.embopress.org/doi/full/10.15252/embj.2023113639" rel="nofollow noopener noreferrer" target="_blank">https://www.embopress.org/doi/full/10.15252/embj.2023113639</a>

Spektrum (inoffiziell)Das entscheidende bei der Kalorienreduktion sind anscheinend gar nicht die Kalorien. Experimente an Taufliegen zeigen, dass die Wahrnehmung von Hunger die Tiere länger leben lässt.<a href="https://anonsys.net/search?tag=Fasten" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Fasten</a> <a href="https://anonsys.net/search?tag=Kalorienreduktion" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Kalorienreduktion</a> <a href="https://anonsys.net/search?tag=Ern%C3%A4hrung" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Ernährung</a> <a href="https://anonsys.net/search?tag=Langlebigkeit" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Langlebigkeit</a> <a href="https://anonsys.net/search?tag=Altern" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Altern</a> <a href="https://anonsys.net/search?tag=Alterung" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Alterung</a> <a href="https://anonsys.net/search?tag=Histone" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Histone</a> <a href="https://anonsys.net/search?tag=Hunger" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Hunger</a> <a href="https://anonsys.net/search?tag=Proteine" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Proteine</a> <a href="https://anonsys.net/search?tag=Aminos%C3%A4ure" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Aminosäure</a> <a href="https://anonsys.net/search?tag=Nahrung" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Nahrung</a> <a href="https://anonsys.net/search?tag=Drosophila" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Drosophila</a> <a href="https://anonsys.net/search?tag=Medizin" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Medizin</a> <a href="https://anonsys.net/search?tag=Biologie" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Biologie</a> <a href="https://www.spektrum.de/news/fasten-hungergefuehl-allein-verlangsamt-alterung-bei-fliegen/2144856" rel="nofollow noopener noreferrer" target="_blank">Hungergefühl allein verlangsamt Alterung bei Fliegen</a>

PLOS BiologyDuring asymmetric <a href="https://fediscience.org/tags/CellDivision" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CellDivision</a> of <a href="https://fediscience.org/tags/Drosophila" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Drosophila</a> male <a href="https://fediscience.org/tags/GermlineStemCells" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#GermlineStemCells</a> (GSCs), <a href="https://fediscience.org/tags/histone" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#histone</a> H3 is preferentially inherited by the GSC, while H3.3 is not; @ChenLabJHU reveals that a single amino acid (A31/S31) underlies these inheritance patterns <a href="https://fediscience.org/tags/PLOSBiology" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PLOSBiology</a> <a href="https://plos.io/4221cXG" rel="nofollow noopener noreferrer" target="_blank">https://plos.io/4221cXG</a>

The EMBO JournalPIF7-mediated <a href="https://sciencemastodon.com/tags/epigenetic" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#epigenetic</a> reprogramming promotes the <a href="https://sciencemastodon.com/tags/transcriptional" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#transcriptional</a> response to shade in <a href="https://sciencemastodon.com/tags/Arabidopsis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Arabidopsis</a>Chuanwei Yang et al.find when a plant grows in shade, transcription factor PIF7 triggers the adaptive growth response by guiding H3.3 deposition via the <a href="https://sciencemastodon.com/tags/histone" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#histone</a> chaperone <a href="https://sciencemastodon.com/tags/ASF1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ASF1</a><a href="https://www.embopress.org/doi/10.15252/embj.2022111472" rel="nofollow noopener noreferrer" target="_blank">https://www.embopress.org/doi/10.15252/embj.2022111472</a>

The EMBO JournalSurprising interplay between <a href="https://sciencemastodon.com/tags/SMC5" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#SMC5</a>/6 and <a href="https://sciencemastodon.com/tags/transcription" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#transcription</a>-regulating <a href="https://sciencemastodon.com/tags/PAF1" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#PAF1</a> complexes in <a href="https://sciencemastodon.com/tags/Arabidopsis" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#Arabidopsis</a> <a href="https://sciencemastodon.com/tags/DNAdamage" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#DNAdamage</a> response: Shunping Yan and colleagues find them to interact and recruit E2/E3 enzymes for <a href="https://sciencemastodon.com/tags/histone" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#histone</a> H2B <a href="https://sciencemastodon.com/tags/ubiquitination" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ubiquitination</a> at DNA double-strand breaks <a href="https://www.embopress.org/doi/10.15252/embj.2022112756" rel="nofollow noopener noreferrer" target="_blank">https://www.embopress.org/doi/10.15252/embj.2022112756</a>

Alexis VergerHello <a href="https://fediscience.org/tags/ScienceMastodon" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#ScienceMastodon</a> Twitter refugees<a href="https://fediscience.org/tags/introduction" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#introduction</a> I am a 🇫🇷 molecular & structural biologist working at the CNRS. I study the molecular mechanisms that control human gene expression focusing on <a href="https://fediscience.org/tags/transcription" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#transcription</a> factors & the Pol II machinery Expect to see here a lot of info on <a href="https://fediscience.org/tags/generegulation" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#generegulation</a>, <a href="https://fediscience.org/tags/enhancers" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#enhancers</a>, <a href="https://fediscience.org/tags/histone" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#histone</a> modifications & structural insights into the eukaryotic Transcription Initiation machinery. <a href="https://fediscience.org/tags/CryoEM" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#CryoEM</a> I will also highlight <a href="https://fediscience.org/tags/womeninscience" class="mention hashtag" rel="nofollow noopener noreferrer" target="_blank">#womeninscience</a> to give them the visibility they deserve

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